This concise yet comprehensive text introduces the essential concepts of bioprocessing—internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information—to traditional chemical engineers and those in related disciplines. It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the application of these principles to modern biotechnology for production of pharmaceuticals and biologics, solution of environmental problems, production of commodities, and medical applications.

• NEW - Concepts of validation and Good Manufacturing Practice (GMP) are introduced.

  • Helps students to better understand regulatory constraints on bioprocess development. Ex.___

• NEW - Updated coverage of concepts.

  • Shows students the connection between traditional ideas and emerging areas—such as tissue engineering and gene therapy. Ex.___

• NEW - Material on functional genomics and cellular engineering.

  • Provides students with new developments in biology as they impact bioprocess engineering. Ex.___

• NEW - Expanded discussion of modeling approach.

  • Presents students with a clarified section on models in continuous cultures and adds cybernetic modeling. Ex.___

• NEW - Expanded coverage of chromatography.

  • Introduces students to discussions of IMAC (immobilized metal affinity chromatography), use of fusion proteins, and porous supports. Ex.___

• NEW - Expanded sections on metabolic engineering, animal cell culture, and protein processing.

  • Offers students information on analysis of metabolic pathways, bioreactor considerations for animal cells, and includes some recent examples. Ex.___

• NEW - Additional examples and homework problems—e.g., on topics such as enzyme reaction; reactor operation and scale-up; purification; waste treatment; and genetically engineered cells.

  • Enables students to more thoroughly test their understanding of applied concepts. Ex.___

• NEW - Reorganized coverage.

  • Gives students a more logical presentation of genetic instability, strategies for genetic engineering, and then an approach to selection of host expression system for production of a heterologous protein. Ex.___

• Emphasis on novel bioprocessing technologies.

  • Provides students with discussions on metabolic pathways and regulation, bioreactors, and separation processes. Ex.___

• Coverage on production of proteins from recombinant DNA technology.

  • Allows students to critically compare and evaluate the various techniques involved. Ex.___

• Applications—To special systems and the particular characteristics of mixed cultures; genetically engineered cells; and plant and animal cells.

  • Reinforces the previously covered engineering and biological concepts while providing more detailed information about important new biological systems. Ex.___

• Chapter-end suggested readings.

  • Encourages students to obtain a more in-depth understanding of key biological and engineering concepts. Ex.___

• Concepts of validation and Good Manufacturing Practice (GMP) are introduced.

  • Helps students to better understand regulatory constraints on bioprocess development. Ex.___

• Updated coverage of concepts.

  • Shows students the connection between traditional ideas and emerging areas—such as tissue engineering and gene therapy. Ex.___

• Material on functional genomics and cellular engineering.

  • Provides students with new developments in biology as they impact bioprocess engineering. Ex.___

• Expanded discussion of modeling approach.

  • Presents students with a clarified section on models in continuous cultures and adds cybernetic modeling. Ex.___

• Expanded coverage of chromatography.

  • Introduces students to discussions of IMAC (immobilized metal affinity chromatography), use of fusion proteins, and porous supports. Ex.___

• Expanded sections on metabolic engineering, animal cell culture, and protein processing.

  • Offers students information on analysis of metabolic pathways, bioreactor considerations for animal cells, and includes some recent examples. Ex.___

• Additional examples and homework problems—e.g., on topics such as enzyme reaction; reactor operation and scale-up; purification; waste treatment; and genetically engineered cells.

  • Enables students to more thoroughly test their understanding of applied concepts. Ex.___

• Reorganized coverage.

  • Gives students a more logical presentation of genetic instability, strategies for genetic engineering, and then an approach to selection of host expression system for production of a heterologous protein. Ex.___

Preface to the Second Edition.


Preface to the First Edition.

I. INTRODUCTION.

II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE.

III. ENGINEERING PRINCIPLES FOR BIOPROCESSES.

IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS.

Biochemical Engineering  [PTG: PRENTICE HALL PROFESSIONAL]   (Chemical Engineering)

DR. MICHAEL L. SHULER is Professor in the School of Chemical Engineering, Cornell University. His areas of research include structured models, heterologous protein expression systems, cell culture analogs for pharmacokinetic models, in-vitro toxicology, plant-cell tissue culture, microbial functional genomics, and bioremediation.

DR. FIKRET KARGI is Professor of Environmental Engineering at Dokuz Eylul University in Ismir, Turkey. His current research includes bioprocessing of wastes for production of commercial products, development of novel technologies for biological treatment of problematic wastewaters, nutrient removal, and novel biofilm reactor development.

The complete, fully updated introduction to biochemical and bioprocess engineering.

Bioprocess Engineering, Second Edition is a comprehensive update of the world's leading introductory textbook on biochemical and bioprocess engineering. Drs. Michael L. Shuler and Fikret Kargi review the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve consistent control over biological activity. This edition reflects powerful advances that are transforming the field, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA. It introduces techniques with broad application to the production of pharmaceuticals, biologics, and commodities; to medical applications such as tissue engineering and gene therapy; and for solving critical environmental problems. This new edition includes:

• Essential biological basics: microorganism structure and functions, major metabolic pathways, enzymes, microbial genetics, kinetics, and stoichiometry of growth
• New coverage of posttranslational processing of proteins-an essential technique for manufacturing therapeutic proteins
• In-depth coverage of animal cell culture processes
• New coverage of noncarbohydrate metabolism
• Functional genomics and cellular engineering: concepts, techniques, and applications
• Applying bioprocess engineering approaches to biomedical applications
• Nonconventional biological systems applications, including host-vector systems for producing proteins from recombinant DNA
• Extensive coverage of mixed cultures, including advanced wastewater treatment processes
• Expanded coverage of modeling, including models in continuous cultures and cybernetic modeling
• How the rapidly evolving governmental regulatory environment constrains bioprocess design and modification

Bioprocess Engineering, Second Edition makes extensive use of illustrations, examples, and problems, and contains extensive references for further reading as well as a detailed appendix describing traditional bioprocesses.

Solutions Manual, 2/E
Shuler & Kargi
©2002  |  Prentice Hall  |  Paper  |  Available on Demand   What's this?
ISBN-10: 0130895377  |  ISBN-13: 9780130895370
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